Safety Evaluation and Toxicity Testing Using In Vitro Methods

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN

development of in vitro methods for toxicity testing of workplace air contaminants

while the oecd test guidelines and mostly animal assays have been used to study the toxic effects of chemicals for many years, very little is known about the potential toxicity of vast majority of inhaled chemicals. considering large number of chemicals and complex mixtures present in indoor and outdoor air, heavy reliance on animal test methods appear to be not adequate. continuing scientific ...

Using PCR and culture methods for Mycoplasma testing

Mycoplasma contaminants can be considered important not only for their roles as pathogens but also they may indicate that insufficient care has been taken during vaccine manufacture or quality control. The purpose of this study was to test the poliomyelitis vaccines for Mycoplasma by culture and polymerase chain reaction (PCR) methods. During 2008 to 2009, a total of 47 lots of oral poliomyelit...

In vitro models for liver toxicity testing.

Over the years, various liver-derived in vitro model systems have been developed to enable investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices, isolated microsomes, perfused liver, immortalized cell lines, and primary hepatocytes have been used extensively. Immortalized cell lines and primary isolated liver cells are currently most widely used in vitro mod...